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They: Support overall cell function and energy production
These results suggested that not all statins are equally effective in clinical settings, and further research into optimal dosing and specific statin classes is warranted
doi: 10.1007/s12640-015-9584-2 89
36 High levels of tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and interleukin-1 (IL-1) induce a neuroinflammatory response in the brain
Therapeutic modulation of this balance is emerging: for example, overexpression of Angiotensin-Converting Enzyme-2 (ACE2) shifts microglia toward the protective M2 phenotype, reducing dopaminergic neurodegeneration
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