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6a), along with enhanced mesenchymal cellular morphology (Fig

For example, PINK1 and Parkin loss of function impair mitophagy and cause accumulation of damaged mitochondria, leading to enhanced electron leakage and formation of superoxides 11,12,13

Elevated MMA levels in patients with vitamin B12 deficiency can contribute to myelin damage (myelopathy) and, consequently, peripheral and autonomic neuropathy ( Cobalamin deficiency can lead to neurological manifestations such as progressive axonal demyelination, impaired peripheral and sensory nerve function, areflexia, loss of proprioception and vibration sensitivity, and subacute combined spinal cord degeneration (70)

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