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and Livon Labs, and conducted under the Declaration of Helsinki (2013) and ICH E6(R2) Good Clinical Practice guidelines

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Sweeney et al., 2018b)

Conclusions: Sub-chronic consumption of sucrose and aspartame induces hippocampal neurotransmitter dysregulation and oxidative stress, contributing to cognitive impairment, whereas natural sweeteners, particularly stevia and date sugar, exhibit neuroprotective effects

Integration of local IGF-I/IGF-IR signaling with systemic hormones Integration with GH Although it is well established that GH stimulates hepatic gene expression to make and supply IGF-I to the circulation, recent studies suggest that changes in circulating IGF-I levels may be an indicator of GH status, but may not be directly involved in controlling local functions in non-hepatic tissues, including bone (68)