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It is interesting to note that in vivo treatment with chloroquine, a potent inhibitor of lysosomal degradation via its effects of acidification of the lysosomal compartment and thus on endosome fusion with the lysosome, leads to decreased incidence of diabetes in NOD mice (50) and to improved response in a glucose tolerance test in NOD mice (51)

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The visit is typically quick, and most clients can return to their normal routine right away