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With the current pandemic, COVID-19 is a primary research target, and scientists and physicians are investigating a wide array of intervention strategies including the use of methods for blunting the inflammatory states that are characteristic of the virus
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While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51
Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption
& Dionisi-Vici, C
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