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This is especially relevant in age-related decline where mitochondrial function often deteriorates

This FDA review signals a shift

[DOI] [PubMed] [Google Scholar] Seninde, D

Shen and colleagues, in a 2019 study, showed that madecassoside, a major Centella compound, both calmed inflammatory signaling and improved skin hydration markers, including hyaluronan production by dermal fibroblasts, and a 2024 review of topical Centella in wound healing reinforces the collagen-synthesis and anti-inflammatory mechanisms

the level of ROS can be dramatically increased by external stimuli or internal stresses and can be toxic to cells [26]