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Expression of CD14 (as well as CD68) is increased in the spinal cords of ALS patients and in mSOD1 mouse models [118, 136], indicating that mSOD1 activation of microglia through CD14 could take place in vivo

5.1.3 Modulating immune and inflammatory pathways Targeting key regulators such as NF-KB and Nrf2 can not only reduce proinflammatory cytokine production but also indirectly rebalance iron homeostasis

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GSSG levels were higher in BAL fluid from SA as compared with that from HCs and were marginally elevated in M/M (overall P = 0.015)