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inhibition of VMAT2 reduces available dopamine that can be released into the synaptic cleft, which can reduce the symptoms associated with dopamine hypersensitivity

For the heart rate, at time points 0 and 10 min after administration there were no significant differences between the groups, while later on there were significant differences between Mel and Dex groups: patients receiving Dex by any route of administration had lower heart frequencies (after 10 and 60 min, p = 0.003

Think of these junctions like the grout between tiles

Picture of Pleurotus shown in Figure 8Cn