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Hey, Ive been waiting to talk to you, man, he says in his signature sweetly stoned lilt and that last word, man, sounds exactly the way hes been saying it since Cheech and Chong became underground breakouts in the early 1970s thanks to their radical, sketch-based LPs

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During insulin exocytosis, it is possible that the calpain-10 protease is activated in response to Ca 2+ influx, partially proteolyzing the synaptosome-associated protein 25 (SNAP25), triggering the exocytosis of insulin (74)

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