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By applying a reverse translational approach that evaluates compounds with emerging clinical efficacy, we demonstrated that semaglutide, tirzepatide, and retatrutide blunt alcohol interoceptive/subjective effects, potentially clarifying a clinically meaningful mechanism

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Collectively, these mechanisms establish a connection between MASLD and diastolic dysfunction, arrhythmias, and a heightened risk of HFpEF [36]

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