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Complementarily, IGF-1R preferentially activates IRS-2 [120] as it was found that IRS-2 contains a KLRB domain that functions to block the tyrosine kinase domain in the cytoplasmic region of the IR, and that such does not happen in the IGF-1R

doi: 10.1111/jnc.13361 23 ChangY

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Balbi MD, Crivellenti LC, Zuccolotto DC, Franco LJ, Sartorelli DS (2019) The relationship of flavonoid intake during pregnancy with excess body weight and gestational diabetes mellitus