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This also raises the question whether PARP activity in BRCA1/2-deficient tumors produces a similar metabolic phenotype via NAD + depletion and whether the use of a PARP inhibitor (e.g., olaparib) to treat these tumors 10 might restore NAD + levels and counterbalance GAPDH inhibition by other oxidative agents

Although ROS levels arent typically measured in routine fertility evaluations, antioxidants like carnitine, naturally found in the male reproductive system, can help reduce oxidative stress and potentially repair sperm damage

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It should be noted that the staining intensity was also higher in the PDL9 group