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The clamps were performed in conscious animals a few days later after rats completely recovered from surgery

The medication (morphine (16 mg/kg s.c.), the tested agents (gastric pentadecapeptide BPC 157 (10 pg, 10 ng and 10 g/kg i.p.), naloxone (10 mg/kg s.c.), haloperidol (1 mg/kg i.p.) or saline (5 ml/kg i.p.) was given accordingly at either 30 min, 20 min or 10 min before the first assessment (time "0"), and subsequently, the mice were assessed at 15, 30, 45, 60, 90, 120, 150 and 180 min intervals (time "+")