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Mild nausea was reported in five (14%) VK2735-treated subjects

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The presence of the lipid modification promotes increased binding to plasma albumin, which under experimental conditions translates into increased structural stability and prolonged retention of the active biological form

doi: 10.1016/j.dmpk.2017.11.001 129 ManachCScalbertAMorandCRmsyCJimnezL

Thus, the rarity of perioperative pulmonary aspiration is an important limitation in our cohort of 426 patients, of whom 81 received no sedation, leaving only 345 in actual risk of perioperative pulmonary aspiration