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Abstract Enteroendocrine L-cell derived peptide hormones, notably glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2), have become important targets in the treatment of type 2 diabetes, obesity and intestinal diseases

Understanding these considerations can help you select a dosing schedule that maximizes adherence and minimizes disruption to your daily life

We further co-cultured ND neurones with primary cultures from transgenic mice expressing Gq-DREADD under the control of the proglucagon promoter, thus enabling cell-specific stimulation of L-cells (Fig

Hyperactivated PI3K phosphorylates and activates Akt, compartmentalized in the plasma membrane

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