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Among the 36 smokingoutcome pairs analyzed, smoking fracture was the only binary riskoutcome pair, which was due to limited data on the doseresponse risk of smoking on fracture 202

Cigarettes burn at temperatures ranging between 600-800C to produce tobacco smoke, which contains more than 5,000 identified constituents, 93 of which have been identified by the FDA as harmful and potentially harmful constituents (HPHCs) linked to the five most serious health effects of cigarette smoking (cancer, cardiovascular disease, respiratory effects, reproductive problems, and addiction)

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