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ECL1 forms two hydrogen bonds with Q23 P (via W214 ECL1 ) and E27 P (via Q211 ECL1 ), as well as stacking interaction with F28 P (via W214 ECL1 )

L., Carter, D

It is essential to rule out unrelated medical conditions that cause sweating, including thyroid disorders (particularly hyperthyroidism), infections, malignancies, menopausal or perimenopausal vasomotor symptoms, medication effects (such as antidepressants or opioids), or other endocrine abnormalities, particularly if sweating is persistent, severe, or accompanied by other concerning symptoms

Gynecological Endocrinology , 15(1), 3-12

Conditions such as systemic lupus erythematosus (SLE) are not included, despite their potential to cause pre-senile dementia through mechanisms like autoimmune antibodies targeting sodium channels on glutamatergic neurons [495]