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The study was conducted from December 2019 to April 2022, and the participant results after 36 weeks of taking tirzepatide indicate: For participants taking 5 mg of tirzepatide, there was an average reduction in systolic blood pressure of 7.4 mm Hg

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If NREM oscillations are necessary for the synaptic capture of PRPs, manipulating these oscillations should alter the synaptic mRNA content

A 2025 JAMA Psychiatry trial (Hendershot et al.) tested lower-dose semaglutide over nine weeks and found reductions in some laboratory measures with smaller real-world effects, suggesting the higher 2.4 mg dose may matter