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In recent years, a growing number of methods for p53-based therapy, such as the use of small molecules that can inhibit the interaction between p53 and its negative regulators, mouse double minute 2/4 (MDM2/4), small molecules that can reactivate the function of mutant p53, and drugs that target specific types of p53 mutants, have emerged

Aggregation can alter biological activity and may increase the likelihood of an immune response

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DISCUSSION DISCUSSION This is the first prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial that evaluated the effects of carnitine on quality of life and liver function

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