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Mollica G, Bonafe L, Russo M et al (2020) L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet

This suggests that intestinal L cells respond to gut barrier disruption by releasing GLP-1, which involves toll-like receptor 4 (TLR4) signalling, and that Akkermansia plays a critical role by directly inducing L cells to release GLP-1 [9]

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The liver orchestrates lignan metabolism, with cytochrome P450 enzymes (CYP3A4 and CYP2B1) catalyzing biotransformation into multiple metabolites (57)

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