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Inform adult patients with type 2 diabetes mellitus on an insulin secretagogue (e.g., sulfonylurea) or insulin that they may have an increased risk of hypoglycemia when using SAXENDA and to report signs and/or symptoms of hypoglycemia to their healthcare provider [see Warnings and Precautions (5.4)]

As drug levels fall, the glucose-dependent insulin secretion and glucagon suppression effects wane, often resulting in rising blood glucose levels

Additionally, the time required to complete the enzymatic activity measurements was prolonged, and the method needed to be more easily adaptable to microplate readers due to the necessity of protein precipitation

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Investigational protocols suggest that administration prior to sleep cycles may reinforce Slow-Wave Sleep (Deep Sleep), facilitating neurocognitive recovery and repair