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Ozempic mimics the glucagon-like peptide-1 receptor agonist (GLP-1 RAs) hormone in the body, which helps regulate blood sugar levels by increasing the secretion of insulin

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Lixisenatide rescues spatial memory and synaptic plasticity from amyloid protein-induced impairments in rats

Both candidates are designed to move beyond single-pathway GLP-1 therapy, but they take very different routes: CagriSema combines an amylin analog with semaglutide, while Retatrutide compresses GIP, GLP-1, and glucagon agonism into one investigational peptide