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By reducing caspase-3 activation, A1AT prevents programmed cell death, which is often induced by oxidative stress ( Finally, A1AT regulates the activity of proteases, enzymes that degrade components of the extracellular matrix

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Bortezomib is a proteasome inhibitor used as a first-line treatment for multiple myeloma, a type of blood cancer characterized by excessive proteasome activity

This suggests that glutathione and inflammation are in a very tight, mutual relationship