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Considering that PDCs increased the local concentration of cytotoxic agents in tumor tissues, they can reduce cytotoxic effects to normal tissues and increase therapeutic efficacy

3 To help guide dosing decisions, use the estimated glomerular filtration rate (eGFR) instead of the serum creatinine (SCr) level, because the SCr can translate into a variable range of eGFRs ( TABLE 1 )

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Jog NR, Caricchio R (2014) The role of necrotic cell death in the pathogenesis of immune mediated nephropathies