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Intranasal delivery extends the effective CNS half life because the peptide is transported directly along olfactory and trigeminal nerve pathways into cerebrospinal fluid and hippocampal interstitial space, bypassing systemic circulation and hepatic metabolism

10.1016/j.amjcard.2024.01.02438336081 173 Ayoub M, Mashayekhi K, Behnes M, et al

The treatment period lasted 4-7 weeks before significant effects were observed

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