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However, phase 2 clinical trials did not show any significant clinical benefits for patients with metastatic CRPC [118]

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In addition to lowering blood glucose, reducing food intake, and delaying gastric emptying (20, 28, 29), it also reduces body mass (2, 3), reduces liver sugar output, and increases insulin sensitization (22)

Am J Manag Care 31(8):e228e34 Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G (2012) Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines