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Animal studies suggest that local or systemic use of deferoxamine may significantly alleviate OA cartilage degradation and inhibit ferroptosis markers in chondrocytes by activating the Nrf2 pathway (54)

Despite its promising applications, further studies and precise usage protocols are essential to fully understand its safety profile and effectiveness in clinical settings

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An elevated expression of GSTs, combined with high GSH levels, can increase the rate of conjugation and detoxification of chemotherapy agents, thus reducing their effectiveness [73]

Side Effects and Safety Considerations Common: Mild injection site redness (resolves within an hour), transient fatigue during the first one to two days of use, and occasional light headache