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Nature (2009) 462(7269):10812

2-adrenoceptor agonists Clonidine gel: A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial showed that topical clonidine gel significantly reduced the level of pain in subjects with DN in whom there are functional (and possibly sensitized) nociceptors in the affected skin

2021;33:e1906539 lvarez K, Rojas M

Primary outcomes, energy expenditure and substrate utilization, were measured before and for 6 h after ingestion of the liquid test meal, using a ventilated hood system (Omnical, Maastricht University, The Netherlands) 47