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Recommendations for Those on T4-Only Medications T4-only medication (such as Synthroid, Levoxyl, Tirosint, Eltroxin, and generic levothyroxine) has a five- to nine-day half-life, which means that once you have become stable on the current dosage, it can take up to nine days for 50 percent of the dose to clear the body

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[2, 5, 6, 30, 31] However, there is no evidence that vitamin B12 deficiency directly causes joint painjust the study mentioned above

Jumping directly to 10 mg would likely cause severe gastrointestinal side effects and is not recommended under any circumstances