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Tolessa T, Gutniak M, Holst JJ, Efendic S, Hellstrom PM

In one of the longest published studies until today (with a follow-up of 6 years) it was clearly shown that in patients with T2D and NAFLD the severity of both steatosis and fibrosis were strongly and inversely related to the Matsuda Index of insulin sensitivity, emphasizing the crucial role of PIO (currently the most well-studied TZD) that targets IR directly to its genesis [128]

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Fat tissue produces excess estrogen, which can lead to several types of cancer

Dose, frequency, and cycle length determine the rest