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HSPGs have a role in several pathways in dopaminergic cells (Figure 1), such as being an essential modulator in diencephalon spinal mechanisms of DA cells (Kastenhuber et al., The Ca +2 flux between the endoplasmic reticulum and mitochondria is mediated by the AKT pathway

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In contrast, alternative approaches like Nambudripads Allergy Elimination Techniquesa nonconventional method combining acupressure and muscle testinghave been proposed but lack scientific validation or robust clinical evidence [186]

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