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In the phase 3 TRIUMPH-1 obesity trial (2,339 adults with obesity or overweight without diabetes), the 12 mg dose produced an average weight loss of 28.3% at 80 weeks, among the largest reductions recorded in obesity pharmacotherapy, with around one third of participants reaching a healthy body weight (BMI 25), alongside improvements in knee osteoarthritis pain and moderate-to-severe obstructive sleep apnoea evaluated in parallel