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The goal is to avoid the modest additional concentration effect that dehydration can add on top of your actual alcohol intake, and to protect your general wellbeing

Mol Neurobiol

However, the limited human clinical trial data means that the long-term safety profile in humans is not fully characterized

A method for preventing drug-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent selected from a JNK inhibitor, a TRPV modulator, a MET channel inhibitor, and an otoprotectant to the individual in need thereof, wherein the pharmaceutical composition is administered prior to onset of therapy with the drug, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration

This is the second large and under-discussed divergence between the DSIP literature and contemporary practice, and it compounds the dose gap described above