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PDRN is fragmented DNA that comes mostly from the sperm cells of salmon trout or chum salmon

The addition of BP in the diet of freshwater fish has led to improved immune status and growth, reduction of the mortality caused by Aeromonas hydrophila, and increase in the number of phagocytic cells (i.e., neutrophils and monocytes) in Nile tilapia ( Oreochromis niloticus ) (153)

Non-neuronal cells appear to significantly contribute to neuronal loss in diseases such as amyotrophic lateral sclerosis (ALS), Parkinson, and Alzheimers disease

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While direct drug interactions are unlikely based on known mechanisms, the lack of safety studies and standardized formulations means healthcare providers cannot definitively assess safety or benefit