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Randomised withdrawal trials in this class consistently show substantial weight regain after discontinuation, and a 2026 review in EClinicalMedicine reports that roughly two-thirds of lost weight is typically regained within a year of stopping

Large reviews of human data from 2024 to 2025 have not shown an increased risk of other cancers with these medications

These potential benefits make Metformin an attractive option for both the prevention and treatment of cancer

Addict Biol 18: 487-495

REDEFINE 1 Phase 3 data demonstrated that CagriSema achieved a mean 22.7% weight reduction at week 68, exceeding either agent used alone, indicating the two compounds function more effectively in combination than as direct competitors [3]