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In more severe cases, clinically significant interstitial nephropathy develops, mediated by deposition of MSU crystals in the physiologic pH milieu of the renal medullary interstitium (a condition termed gouty nephropathy, which impairs renal function)

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It is important to note that B12 levels should ideally be measured before commencing replacement therapy, as supplementation rapidly normalises biochemical markers, potentially obscuring the diagnosis

But if you pull up these three sources, that was based on studies on mice, rats, and in petri dishes