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Intestinal microbes are also bale to secrete neurotransmitters like Gamma-aminobutyric acid (GABA), 5-HT, catecholamine, and histamine (140)

Multiple injectable peptidic GLP-1R agonists are approved for the treatment of Type 2 diabetes mellitus (T2DM) ( 8 ), including liraglutide which is also approved for the treatment of obesity ( 9 )

Prespecified subgroup analyses Subgroup analyses were conducted to examine variations in risk related to the desired outcomes among the GLP-1 RAs users

Redox-sensitive cerium oxide nanoparticles protect human keratinocytes from oxidative stress induced by glutathione depletion

ACSL4 catalyzes the reaction of PUFAs to polyunsaturated fatty acid-coenzyme A (PUFA-CoA), and then the PUFA-CoA undergoes esterification by lysophosphatidylcholine acyltransferase 3 (LPCAT3) to become polyunsaturated fatty acid-phospholipids (PUFA-PLs), which are then oxidized by reactive oxygen species (ROS) to cytotoxic phospholipid hydroperoxides (PL-OOH), leading to cell death through membrane modification (Liu et al., 2025