SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease
The compound might contribute to the formation of thiohydantoin derivatives in vitro by a chemical reaction with thyroid hormones, according to the following scheme: ITCs and an amino acid may react to form a thiocarbamyl derivative, the subsequent cyclization of which may yield thiohydantoin
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The pairing is a frequently studied model system in pre-clinical somatotroph research where two complementary upstream pathways converge on the same pituitary cell population
Chen H, Dunk MM, Wang B, Zhao M, Shen J, Zong G, et al