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Hostility: Users exhibit increased aggression or irritability, particularly when challenged about their drug use

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Results Globally, while the ASMR of LC decreased by 1.49% (95% CI, 1.411.57%) per year between 1990 and 2019, the number of deaths from LC has increased 41.0% to 123.4 thousand in 2019

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At 75.4, life expectancy from birth in these counties is, on average, more than three years shorter than in counties experiencing fewer structural barriers (78.5 years) (map at right)