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The most common side effects of these drugs are mild gastrointestinal (GI) issues

From Kliegman RM, Stanton BF, Schor NF, et al., eds

Medication-Specific Adjustments Guidelines from the FDA and KDIGO-ADA 2022 indicate that liraglutide (Saxenda), semaglutide (Wegovy, Ozempic), and tirzepatide (Zepbound, Mounjaro) do not require dose adjustments for CKD patients

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The nuclear factor-B (NF-B) signaling pathway is a central regulator orchestrating inflammatory activation [50]