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Cortisol affects neuronal mitochondrial function in a biphasic manner : Low, normal levels of cortisol increase mitochondrial function Chronically high levels of cortisol decrease mitochondrial function.[ref] Chronic stress alters cortisol levels and thus can affect mitochondrial function in the brain

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Typically, groundwater is thought of as water flowing through shallow aquifers, but, in the technical sense, it can also contain soil moisture, permafrost (frozen soil), immobile water in very low permeability bedrock, and deep geothermal or oil formation water