The severity and progression of symptoms can vary greatly from person to person
Cardiovascular (Heart and Blood Vessel) Complications In rare but serious cases, B12 replacement can lead to heart and blood vessel problems: Shortness of breath Peripheral edema (swelling in legs and arms) Rapid weight gain Pulmonary edema (fluid in lungs) Congestive heart failure (heart cannot pump effectively) Blood clots in vessels These complications arise from increased blood volume, thicker blood, and sudden changes in how hard the heart needs to work
doi: 10.1136/BMJDRC-2016-000219 176 IfieERussellMADhayalSLeetePSebastianiGNigiLet al
Also, crosstalk with other signaling pathways such as transforming growth factor-beta (TGF-) has led to carcinogenesis and resistance to targeted therapies in human lung, pancreatic, and breast tumor xenografts [17]
TB-500 and thymosin beta-4 for bone repair Thymosin beta-4 (abbreviated as Tb4) is a naturally occurring 43-amino acid peptide that plays fundamental roles in cellular migration, tissue regeneration, and wound healing throughout the body