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MSU crystals activate the p300/CBP acetyltransferase, inducing H3K27ac enrichment at enhancer regions of inflammatory genes (e.g., CXCL8 and PTGS2 ) within macrophages, thereby prolonging inflammatory responses (Punzi et al., 2025)

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High-level GSH not only facilitates the elimination of ROS generated during cancer cell metabolism but also helps cancer cells overcome drug-induced ROS stress, conferring drug resistance 38,40

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