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Moreover, the masking of sperm surface phosphatidylserine residues potently inhibited fertilization, thus identifying this ligand as a potential key player in sperm-oocyte fusion (101)

NRF2 also controls the expression of glutathione S-transferases (GST) and glutathione peroxidases 2 (GPX2), which are enzymes known for detoxifying epoxide and H 2 O 2 , respectively

doi: 10.1038/s41598-021-97440-y 70 ShiimuraY.HoritaS.HamamotoA.AsadaH.HirataK.TanakaM.et al

28 For example, p70S6K1 phosphorylates MDM2 at Ser166 resulting in polyubiquitination and degradation of p53 and thereby inhibits p53-dependent apoptosis