Large-scale trials are only available for BH 4 , sepiapterin or sapropterin in phenylketonuria (Muntau et al., 2024), an autosomal recessive disorder caused by deficiency of phenylalanine hydroxylase, leading to hyperphenylalaninemia, developmental delay, behavioral problems, and reduced quality of life ( Approaches with preclinical evidence only Promoting transcriptional regulation of eNOS Several compounds have been identified to enhance eNOS transcription and promote NO production
Altogether, these results indicate that pharmacological inhibition of MAOB with KDS2010 effectively mitigates PTSD-associated deficits by reducing aberrant astrocytic GABA, restoring behavioral functions, and supporting the therapeutic potential of MAOB inhibitors in PTSD treatment
Cell Mol
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