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Specifically, PCI34051 blocks the activation of TGF- and p-Smad, reducing the phosphorylation of STAT3 and -catenin in renal tubular cells, and reversing the increase in HDAC8 expression, the increased deacetylation levels of cortical protein and the expression of fibrosis markers (-SMA, collagen 1, and fibronectin) induced by UUO

Chronic exposure

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Additionally, melatonin may activate AMPK/SERCA2a to inhibit Ca 2+ overload and thus decrease calcium-dependent xanthine oxidase and ROS levels, ultimately resulting in dephosphorylation at Ser616 inhibiting migration on the surface of mitochondria and ultimately inhibiting mitochondrial fission in LPS-induced human umbilical vein endothelial cell injury ( 3.3 Melatonin regulates mitochondrial oxidative stress through autophagy As a highly conserved mechanism, autophagy degrades misfolding proteins or damaged organelles, to fulfill the recycling of amino acids and lipids (Xu et al., 2023

According to Guan et al