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The article dates the hormone's identification to 1987, when researchers were studying intestinal hormones and its role in post-meal glucose regulation, and dates the first synthetic GLP-1 receptor agonist, exenatide, to FDA approval for type 2 diabetes in 2005

While this doesnt directly translate to appetite loss like the GLP-1 agonist effect, it does help improve how the body uses food

Ecnoglutide: cAMP signaling-biased GLP-1 receptor agonist