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As the pathological aging model, these mice were administrated DOX in five equal intraperitoneal injections (each containing 2.5 mg kg 1 ) over a period of 2 weeks, with a total cumulative dosage of 12.5 mg kg 1 at 10 weeks of age, and were killed at 18 weeks of age

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Nicotine pouches utilize buccal absorption through the oral mucosa