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A 2021 systematic review in the Journal of the American Academy of Dermatology (Choi et al., JAAD 2021) examined low-dose regimens (0.25 to 0.4 mg/kg/day) and found comparable 12-month remission rates with fewer mucocutaneous side effects, but the FDA label has not incorporated low-dose language as a formal recommendation

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More serious risks - including pancreatitis and thyroid-related concerns - are documented in FDA-approved GLP-1 prescribing information