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J Neurochem 91:667682 de Haan JB, Bladier C, Griffiths P, Kelner M, OShea RD, Cheung NS, Bronson RT, Silvestro MJ, Wild S, Zheng SS, Beart PM, Hertzog PJ, Kola I (1998) Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide

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Human studies showed a protective role of GLP-1R in the progression of coronary atherosclerosis through several pathways associated not only with metabolism but also with the polarization of macrophages

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These include more effective blood glucose control due to their complementary mechanisms of action, improved overall metabolic profiles (such as cholesterol and triglyceride levels), and greater potential for significant and sustained weight loss